What you
can expect

WHEN TAKING VORANIGO®

VORANIGO IS A once-daily pill

The standard dose of VORANIGO is one 40 mg pill taken by mouth.
  • The dose for children 12 years and older who weigh 88 pounds or less (<40 kg) is 20 mg once daily by mouth
Take control of your treatment schedule: CHOOSE A CONVENIENT, CONSISTENT TIME TO TAKE VORANIGO EACH DAY.
When taking VORANIGO, remember to:
  • Take VORANIGO exactly as your healthcare provider tells you
  • Do not change your dose or stop taking VORANIGO without talking to your healthcare provider
  • Take VORANIGO once a day, about the same time each day
  • Swallow VORANIGO pills whole with water. Do not split, crush, or chew the pills
Your doctor can help answer any questions you may have about taking VORANIGO.
Doctor McGranahan.
Hear from a neuro-oncologist
Dr McGranahan explains what to expect and tips for taking VORANIGO.
Watch now

What if I miss a dose of VORANIGO?

If you miss a dose of VORANIGO by less than 6 hours, take the missed dose right away. Take your next dose at your usual time.
If you miss a dose by more than 6 hours, skip the dose for the day. Take your next dose at your usual time.
If you vomit after taking VORANIGO, do not take an extra dose. Take your next dose at your usual time.

Using tobacco or other medications while taking VORANIGO

Smoking tobacco may affect how well VORANIGO works. If you currently smoke tobacco, inform your healthcare provider to discuss your options.
Some medications may affect how VORANIGO works in your body, and VORANIGO may affect how other medications work in your body as well.
Make sure to talk to your healthcare team about all the medications you take, including all over-the-counter medications, vitamins, and herbal supplements.
If you start any new medications while taking VORANIGO, inform all your healthcare professionals so they all have the most current list.

How to store VORANIGO

Store VORANIGO at room temperature between 68 °F and 77 °F (20 °C to
25 °C).
VORANIGO comes with desiccant canisters (drying agents) in the bottle to help keep the medicine dry (protect from moisture). Do not remove the desiccant canister from the bottle. Do not swallow the desiccant canister.
The VORANIGO bottle has a child resistant cap. Keep VORANIGO and all medicines out of reach of children.
Learn why monitoring during treatment with voranigo is important

Reproductive health CONSIDERATIONS

Tell your healthcare provider if you're pregnant or plan to become pregnant as VORANIGO may harm an unborn baby. It may affect fertility in females and males, which can impact the ability to have children. You’re encouraged to discuss family planning options with your healthcare provider, including referral to an onco-fertility specialist.
 For females who can become pregnant:

Will my birth control be affected?

  • VORANIGO may make hormonal birth control stop working. Use nonhormonal birth control (such as diaphragms, IUDs, or condoms) during treatment
    • You should continue to use nonhormonal birth control for 3 months after you stop treatment

Can I breastfeed?

  • You should not breastfeed during treatment and for 2 months after you stop treatment
    • It is not known if VORANIGO passes into breast milk
For males with female partners who can become pregnant:

Should I use contraception?

  • You should use effective contraception during treatment and for 3 months after you stop treatment
  • VORANIGO will not affect your partner’s hormonal birth control
Information about embryo-fetal toxicity and recommendations about VORANIGO during pregnancy are based on studies in animals. The effect of VORANIGO on fertility or pregnancy has not been studied in humans.
VORANIGO Reproductive Considerations Guide.

DOWNLOAD THE
Reproductive Considerations Guide

Get additional information and resources related to family planning with VORANIGO.

HOW IS THE

length of treatment

WITH VORANIGO DETERMINED?

Treatment with VORANIGO does not follow a predetermined number of months. VORANIGO can be taken as long as the disease does not progress or as long as the patient can tolerate the medication. Over half of people taking VORANIGO in the INDIGO clinical trial were on the treatment for over 1 year.
VORANIGO WAS
STUDIED IN PEOPLE WITH IDH-MUTANT GLIOMA
See the results
Get helpful resources
FOR TALKING TO YOUR DOCTOR ABOUT VORANIGO
Your Toolkit
Are you eligible for VORANIGO?
Talk to your doctor about VORANIGO
The VORANIGO
$0 Copay Program
Important Safety Information
What is VORANIGO?
VORANIGO (40 mg tablets) is a prescription medicine used to treat adults and children 12 years of age and older with certain types of brain tumors called astrocytoma or oligodendroglioma with an isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2) mutation, following surgery. Your healthcare provider will perform a test to make sure that VORANIGO is right for you. It is not known if VORANIGO is safe and effective in children under 12 years of age.
What are the possible side effects of VORANIGO?
VORANIGO may cause serious side effects, including:
  • Liver problems. Changes in liver function blood tests may happen during treatment with VORANIGO and can be serious. Your healthcare provider will do blood tests to check your liver function before and during treatment with VORANIGO. Tell your healthcare provider right away if you develop any of the following signs and symptoms of liver problems:
    • yellowing of your skin or the white part of your eyes (jaundice)
    • dark tea-colored urine
    • loss of appetite
    • pain on the upper right side of your stomach area
    • feeling very tired or weak
What is VORANIGO?
VORANIGO (40 mg tablets) is a prescription medicine used to treat adults and children 12 years of age and older with certain types of brain tumors called astrocytoma or oligodendroglioma with an isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2) mutation, following surgery. Your healthcare provider will perform a test to make sure that VORANIGO is right for you. It is not known if VORANIGO is safe and effective in children under 12 years of age.
What are the possible side effects of VORANIGO?
VORANIGO may cause serious side effects, including:
The most common side effects of VORANIGO include:
Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with VORANIGO if you have certain side effects.
VORANIGO may affect fertility in females and males, which may affect the ability to have children. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects of VORANIGO.
Before taking VORANIGO, tell your healthcare provider about all of your medical conditions, including if you:
Females who are able to become pregnant:
Males with female partners who are able to become pregnant:
Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if VORANIGO passes into breast milk. Do not breastfeed during treatment with VORANIGO and for 2 months after the last dose.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VORANIGO may affect the way other medicines work, and other medicines may affect how VORANIGO works.