FREQUENTLY ASKED
QUESTIONS
FAQs
About VORANIGO®
Is VORANIGO right for me and my glioma?
VORANIGO is for people with Grade 2 astrocytoma or oligodendroglioma with an IDH1 or IDH2 mutation who have had a prior surgery. Only you and your healthcare team can decide if VORANIGO is the appropriate treatment option for you.
How does VORANIGO work?
In astrocytoma and oligodendroglioma, IDH1 or IDH2 mutations result in mutated IDH1 or IDH2 enzymes. VORANIGO is specifically designed to inhibit these mutated enzymes to reduce tumor cell growth and reduce the chance that glioma progresses.
How effective is VORANIGO?
VORANIGO has been shown to increase the length of time a person can live with Grade 2 IDH-mutant astrocytoma or oligodendroglioma without it getting worse.
VORANIGO lowered the chance of disease progression by 61% compared with placebo.
VORANIGO increased the amount of time until people needed their next treatment.
Who can take VORANIGO?
VORANIGO is for:
- Adults and children 12 years of age and older
- Grade 2 IDH1- or IDH2-mutant astrocytoma or oligodendroglioma
- People who have had at least one surgery or biopsy at any prior time for their tumor
- Both people who have not received other anticancer treatments and those whose disease has progressed after other treatments
How should I take VORANIGO?
VORANIGO is a pill taken orally once daily with or without food.
- The standard dose of VORANIGO is one 40 mg pill
- Take VORANIGO exactly as your healthcare provider tells you
- Do not change your dose or stop taking VORANIGO without talking to your healthcare provider
- Take VORANIGO once a day, about the same time each day
- Swallow VORANIGO pills whole with water. Do not split, crush, or chew the pills
Can my other medications affect VORANIGO?
- VORANIGO may interact with other medications that you are taking
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
What are the possible side effects of VORANIGO?
VORANIGO can cause serious side effects, including liver problems. Talk to your doctor about VORANIGO and what to expect before starting treatment.
The most common side effects of VORANIGO include:
- increased liver enzyme levels in the blood
- lack of energy, tiredness
- headache
- COVID-19
- muscle aches or stiffness
- diarrhea
- nausea
- seizure
What if I am or my partner is pregnant, planning to become pregnant, or breastfeeding?
VORANIGO is not recommended for use during pregnancy as it may harm an unborn baby. It may affect fertility in females and males, which can impact the ability to have children. You’re encouraged to discuss family planning options with your healthcare provider, including referral to an onco-fertility specialist.
Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if VORANIGO passes into breast milk. Do not breastfeed during treatment with VORANIGO and for 2 months after the last dose.
Is there financial assistance available for VORANIGO?
You may be eligible for financial assistance programs to help pay for the medication through ServierONE™.
Where can I sign up for financial and personal support?
Visit ServierONE.com to find resources created just for patients, families, and caregivers that can help navigate the glioma journey.
About IDH-mutant glioma
How is glioma diagnosed?
The process of diagnosing glioma begins with symptoms that affect brain function and a brain scan (MRI) that can identify the presence of a tumor. If a tumor is identified, surgery or biopsy is performed and the tumor is tested for mutations, which help determine the glioma type and potential treatment options.
How is glioma treated?
Glioma treatment depends on your specific type of glioma and treatment goals. Mutations can affect prognosis and impact the treatment you and your doctor choose. If you have IDH-mutant glioma, VORANIGO may be right for you.
What monitoring is required for glioma?
Gliomas will need to be monitored with an MRI every 3 to 6 months. You may need additional monitoring depending on your specific needs and treatment.
Are there support groups for glioma?
There are various support groups for people living with glioma.
