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VORANIGO is for people with Grade 2 astrocytoma or oligodendroglioma with an IDH1 or IDH2 mutation who have had a prior surgery. Only you and your healthcare team can decide if VORANIGO is the appropriate treatment option for you.

In astrocytoma and oligodendroglioma, IDH1 or IDH2 mutations result in mutated IDH1 or IDH2 enzymes. VORANIGO is specifically designed to inhibit these mutated enzymes to reduce tumor cell growth and reduce the chance that glioma progresses.

• Adults and children 12 years of age and older
• Grade 2 IDH1- or IDH2-mutant astrocytoma or oligodendroglioma
• People who have had at least one surgery or biopsy at any prior time for their tumor
• Both people who have not received other anticancer treatments and those whose disease has progressed after other treatments

• The standard dose of VORANIGO is one 40 mg pill
  • For pediatric patients weighing <40 kg, the standard dose is one 20 mg pill
• Take VORANIGO exactly as your healthcare provider tells you
• Do not change your dose or stop taking VORANIGO without talking to your healthcare provider
• Take VORANIGO once a day, about the same time each day
• Swallow VORANIGO pills whole with water. Do not split, crush, or chew the pills

• Smoking tobacco may affect how well VORANIGO works
• VORANIGO may interact with other medications that you are taking
• Tell your healthcare provider about your tobacco use and all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

• increased liver enzyme levels in the blood
• lack of energy, tiredness
• headache
• COVID-19
• muscle aches or stiffness
• diarrhea
• nausea
• seizure

Tell your healthcare provider if you're pregnant or plan to become pregnant as VORANIGO may harm an unborn baby. VORANIGO may make hormonal birth control stop working. For females who can become pregnant, use nonhormonal birth control (such as diaphragms, IUDs, or condoms) during treatment and for 3 months after you stop treatment. For males with female partners who can become pregnant, use effective contraception during treatment and for 3 months after you stop treatment.

VORANIGO may affect fertility in females and males, which can impact the ability to have children. You're encouraged to discuss family planning options with your healthcare provider, including a referral to an onco-fertility specialist.

Additionally, you should not breastfeed during treatment and for 2 months after you stop treatment.

Helping your loved one stick to their treatment plan is the best way to support them on their journey. VORANIGO is a once-daily pill, so finding ways to incorporate their daily dose into their routine or setting reminders can help them stay on track.

You may be eligible for financial assistance programs to help pay for the medication through ServierONE™. The $0 Copay Program lowers the out-of-pocket cost of VORANIGO for eligible patients with commercial insurance to as little as $0 per prescription. Terms and conditions, including eligibility restrictions, apply.

The process of diagnosing glioma begins with symptoms that affect brain function and a brain scan (MRI) that can identify the presence of a tumor. If a tumor is identified, surgery or biopsy is performed and the tumor is tested for mutations, which help determine the glioma type and potential treatment options.

Glioma treatment depends on your specific type of glioma and treatment goals. Mutations can affect prognosis and impact the treatment you and your doctor choose. If you have IDH-mutant glioma, VORANIGO may be right for you.

Gliomas will need to be monitored with an MRI every 3 to 6 months. You may need additional monitoring depending on your specific needs and treatment.

IDH-mutant glioma, specifically, is known to spread and can invade nearby brain tissue. Even when surgeons are able to remove all they can see, some cancer cells may still be left behind. These leftover cells can grow slowly over time. Treatment after surgery could help slow the growth of these cells even further.

There are various support groups for people living with glioma.

After a glioma diagnosis, your loved one may be treated by a number of different specialists. These specialists are likely to provide a lot of information about your loved one's diagnosis and treatment. It's normal to feel overwhelmed at this stage. Remember, their care team is there to help. Feel free to ask them questions you have at every stage.