Frequently asked questions about VORANIGO

VORANIGO has been shown to increase the length of time a person can live with Grade 2 IDH-mutant astrocytoma or oligodendroglioma without it getting worse.

At the time the data was analyzed, 72% of people who took VORANIGO did not see their disease progress compared to 46% of people who took placebo.

VORANIGO increased the amount of time until people needed their next treatment.

• Adults and children 12 years of age and older
• Grade 2 IDH1- or IDH2-mutant astrocytoma or oligodendroglioma
• People who have had at least one prior surgery for their tumor

VORANIGO can cause serious side effects, including liver problems. Changes in liver function blood tests may happen during treatment with VORANIGO and can be serious. Your healthcare provider will do blood tests to check your liver function before and during treatment with VORANIGO. Tell your doctor right away if you develop any of the following signs and symptoms of liver problems:

• yellowing of your skin or the white part of your eyes (jaundice)
• dark tea-colored urine
• loss of appetite
• pain on the upper right side of your stomach area
• feeling very tired or weak

The most common side effects of VORANIGO include:

• increased liver enzyme levels in the blood
• lack of energy, tiredness
• headache
• COVID-19
• muscle aches and stiffness
• diarrhea
• nausea
• seizure

VORANIGO is only available with a prescription from a doctor and will come from a specialty pharmacy or from the pharmacy at your hospital or clinic.

You may be contacted by your specialty pharmacy or Servier over the phone. Please keep in mind that this call may come from a number you do not recognize.

Visit ServierONE.com to access our patient services and register online for the Commercial Copay Program at ServierONE-copay.com.

VORANIGO is a pill taken orally once daily with or without food.

• The standard dose of VORANIGO is one 40 mg pill
• Take VORANIGO exactly as your healthcare provider tells you
• Do not change your dose or stop taking VORANIGO without talking to your healthcare provider
• Take VORANIGO once a day, about the same time each day
• Swallow VORANIGO pills whole with water. Do not split, crush, or chew the pills

• VORANIGO may interact with other medications that you are taking
• Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements

• Your healthcare provider will do a pregnancy test before you start treatment with VORANIGO
• You should use effective nonhormonal birth control during treatment with VORANIGO and for 3 months after the last dose. VORANIGO may affect how hormonal contraceptives (birth control) work and cause them to not work well. Talk to your healthcare provider about birth control methods that may be right for you during treatment with VORANIGO
• Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with VORANIGO

• You should use effective birth control during treatment with VORANIGO and for 3 months after the last dose
• Tell your healthcare provider right away if your partner becomes pregnant or thinks she may be pregnant during your treatment with VORANIGO

Tell you healthcare provider if your are breastfeeding or plan to breastfeed. It is not known if VORANIGO passes into breast milk. Do not breastfeed during treatment with VORANIGO and for 2 months after the last dose.